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Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia

✍ Scribed by Sofiyan Saleem; Yun Tai Kim; Takayuki Maruyama; Shuh Narumiya; Sylvain Doré

Book ID
113730436
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
562 KB
Volume
208
Category
Article
ISSN
0165-5728

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Reduced brain injury in CD18-deficient m
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✍ Elena Titova; Robert P. Ostrowski; Christopher G. Kevil; Wenni Tong; Hugo Rojas; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 320 KB

## Abstract Many studies have indicated leukocytes are a major contributor to brain injuries caused by intracerebral hemorrhage (ICH). Leukocyte‐expressed CD18 is important for neutrophil–endothelial interactions in the vasculature, and CD18 deficiency protects against ischemia‐reperfusion injury.