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Reduced acetylcholine sensitivity in dystrophic mouse myotubes in vitro

โœ Scribed by Giulio Cossu; Dr. Fabrizio Eusebi; Mario Molinaro

Book ID
102536123
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
289 KB
Volume
7
Category
Article
ISSN
0148-639X

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โœฆ Synopsis

dystrophic mice was investigated using conventional techniques. Dystrophic rnultinucleate myotubes were found to be less responsive to the ACh with respect to the control preparation. Such a reduced sensitivity to ACh in dystrophic rnyotubes was accompanied by a reduced binding to '251-alpha-bungarotoxin. The possible biological significance of these results on the muscle disease is discussed.

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Acetylcholine receptor and calcium leakage activity in nondystrophic and dystrophic myotubes (MDX)
โœ C. George Carlson ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 942 KB

To determine whether the lack of dystrophin alters the occurrence of calcium leakage activity (CLA) and acetylcholine receptor (AChR) activity, the frequency of each event class was determined from several cell attached patches on nondystrophic and dystrophic (mdx) myotubes. The frequency of CLA obs