Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: Correlation with grade and expression in high-grade prostatic intraepithelial neoplasia
β Scribed by Gregory S. Jack; Alan R. Brash; Sandra J. Olson; Suzanne Manning; Christopher S. Coffey; Joseph A. Smith; Jr; Scott B. Shappell
- Book ID
- 117818277
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 358 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1532-8392
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## Abstract Highβgrade prostatic intraepithelial neoplasia (HGPIN) appears to represent an ideal target for chemoprevention of prostate cancer (PCa). HGPIN responds to androgen ablation and has prostate stem cell antigen (PSCA) mRNA expression. One hundred and seventy two patients with isolated HGP
## BACKGROUND. High grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of human prostate cancer and is commonly found in men undergoing prostatic needle biopsy for suspected cancer. Recent work has demonstrated that pet dogs, like humans, develop PIN spontaneously and in