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Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction

โœ Scribed by Beate Fuchs; Natascha Sommer; Alexander Dietrich; Ralph Theo Schermuly; Hossein Ardeschir Ghofrani; Friedrich Grimminger; Werner Seeger; Thomas Gudermann; Norbert Weissmann

Book ID
113876741
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
631 KB
Volume
174
Category
Article
ISSN
1569-9048

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The molecular mechanisms underlying hypoxic pulmonary vasoconstriction (HPV) are not yet properly understood. Mitochondrial electron transport chain (ETC) and NADPH oxidase have been proposed as possible oxygen sensors, with derived reactive oxygen species (ROS) playing key roles in coupling the sen