Redox rhythmicity: clocks at the core of temporal coherence
✍ Scribed by David Lloyd; Douglas B. Murray
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 267 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Ultradian rhythms are those that cycle many times in a day and are therefore measured in hours, minutes, seconds or even fractions of a second. In yeasts and protists, a temperature‐compensated clock with a period of about an hour (30–90 minutes) provides the time base upon which all central processes are synchronized. A 40‐minute clock in yeast times metabolic, respiratory and transcriptional processes, and controls cell division cycle progression. This system has at its core a redox cycle involving NAD(P)H and dithiol–disulfide interconversions. It provides an archetype for biological time keeping on longer time scales (e.g. the daily cycles driven by circadian clocks) and underpins these rhythms, which cannot be understood in isolation. Ultradian rhythms are the foundation upon which the coherent functioning of the organism depends. BioEssays 29:465–473, 2007. © 2007 Wiley Periodicals, Inc.