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Redox regulation of signal transduction in smooth muscle cells: Protein kinase C inhibition by thiol agents

✍ Scribed by Mohiuddin M. Taher; Anwar S. A. Abd-Elfattah

Book ID
111742150
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
753 KB
Volume
40
Category
Article
ISSN
1521-6543

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## Abstract In certain cell systems, including neonatal vascular smooth muscle (VSM) cells, phorbol esters are growth inhibitory. Here we show that 1, 2‐dioctanoyl‐snglycerol (DiC8), when added 2 h after α‐thrombin, reverses by 95% the induction of DNA synthesis in VSM cells by α‐thrombin. Sphingos