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Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells

✍ Scribed by Aki Ogura; Shigeru Oowada; Yasuhiro Kon; Aki Hirayama; Hironobu Yasui; Shunsuke Meike; Saori Kobayashi; Mikinori Kuwabara; Osamu Inanami


Book ID
116335067
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
550 KB
Volume
277
Category
Article
ISSN
0304-3835

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✍ Tracey D. Bradshaw; Andreas Gescher; George R. Pettit πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 French βš– 711 KB

I 2-0-tetradecanoylphorbol-I 3-acetate (TPA) and bryostatin I are activators of protein kinase C (PKC). TPA is a potent inhibitor of the growth of A549 cells, while bryostatin I exerts a weak antiproliferative effect upon this cell line. We tested the hypothesis that the PKC inhibitor staurosporine