Modulation by staurosporine of phorbol-e
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Tracey D. Bradshaw; Andreas Gescher; George R. Pettit
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Article
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1992
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John Wiley and Sons
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French
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I 2-0-tetradecanoylphorbol-I 3-acetate (TPA) and bryostatin I are activators of protein kinase C (PKC). TPA is a potent inhibitor of the growth of A549 cells, while bryostatin I exerts a weak antiproliferative effect upon this cell line. We tested the hypothesis that the PKC inhibitor staurosporine