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Redox-active iron mediates amyloid-β toxicity

✍ Scribed by Catherine A Rottkamp; Arun K Raina; Xiongwei Zhu; Elizabeth Gaier; Ashley I Bush; Craig S Atwood; Mordechai Chevion; George Perry; Mark A Smith

Book ID
114274634
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
155 KB
Volume
30
Category
Article
ISSN
0891-5849

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## Abstract Early intracellular events responsible for cell‐cycle induction by β‐amyloid (Aβ) in neurons have not been identified yet. Extracellular signal–regulated kinases 1/2 (ERK1/2) have been identified in this pathway, and inhibition of ERK activity prevents cell‐cycle activation and reduces