Redistribution of the water channel protein aquaporin-4 and the K+channel protein Kir4.1 differs in low- and high-grade human brain tumors

Expression pattern of the water channel

Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood–brain barrier disturbance but not with patient survival

✍ Arne Warth; Perikles Simon; David Capper; Benjamin Goeppert; Ghazaleh Tabatabai; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 654 KB

## Abstract Aquaporin‐4 (AQP4), the most prominent CNS water channel, is restricted to the glia limitans and astrocytic endfeet. We previously showed the loss of spatial AQP4 expression in glioblastomas and a redistribution across the cell surface. However, opposing AQP4 functions have been describ