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Redesigning the zinc binding site of human carbonic anhydrase II: structure of a His2Asp-Zn2+ metal coordination polyhedron

โœ Scribed by Kiefer, Laura L.; Ippolito, Joseph A.; Fierke, Carol A.; Christianson, David W.


Book ID
127378411
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
1005 KB
Volume
115
Category
Article
ISSN
0002-7863

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Crystallographic studies of inhibitor bi
โœ A. Elisabeth Eriksson; Per M. Kylsten; T. Alwyn Jones; Anders Liljas ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 961 KB

The binding of four inhibitors--mercuric ion, 3-acetoxymercuri-4-aminobenzenesulfonamide (AMS), acetazolamide (Diamox), and thiocyanate ion--to human carbonic anhydrase II (HCA II) has been studied with X-ray crystallography. The binding of mercury to HCA II at pH 7.0 has been investigated at 3.1 A