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Redefining monosomy 5 by molecular cytogenetics in 23 patients with MDS/AML

✍ Scribed by Angèle Herry; Nathalie Douet-Guilbert; Frédéric Morel; Marie-Josée Le Bris; Marc De Braekeleer


Book ID
114794179
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
495 KB
Volume
78
Category
Article
ISSN
0902-4441

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Amplification within chromosome arm 11q involving the mixed-lineage leukemia gene (MLL) locus is a rare but recurrent aberration in acute myeloid leukemia and myelodysplastic syndrome (AML/MDS). We and others have observed that 11q amplifications in most AML/MDS cases have not been restricted to the