𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Red cell acid phosphatase: Another polymorphism correlated with malaria?

✍ Scribed by R. Palmarino; R. Agostino; F. Gloria; P. Lucarelli; L. Businco; G. Antognoni; G. Maggioni; P. L. Workman; E. Bottini

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
581 KB
Volume
43
Category
Article
ISSN
0002-9483

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The frequency of P^C^ allele for acid phosphatase in fourteen Sardinian villages correlates positively with the altitude and negatively with past malarial morbidity and Gd^Med^ prevalence.

The susceptibility towards hemolytic favism in Sardinian males with G6PD deficiency is dependent on the erythrocyte acid phosphatase and thalassemia phenotypes. Thalassemia trait exerts a protective action only in subjects carrying P^A^ allele for acid phosphatase.

The data suggest that the gradient for malaria morbidity directly or indirectly, through interactions with thalassemia and G6PD polymorphisms, mediated by the habit of eating Vecia faba, may have had a significant role in determining the heterogeneous distribution of acid phosphatase polymorphism in Sardinia. Besides malaria, other environmental factors related with altitude seem to have been very important in shaping the present pattern of distribution of both acid phosphatase and G6PD polymorphisms in Sardinia.

πŸ“œ SIMILAR VOLUMES

Lack of association between psoriasis vu
Lack of association between psoriasis vulgaris and red cell acid phosphatase polymorphism
✍ Gila Matthaei; U. Langenbeck πŸ“‚ Article πŸ“… 1978 πŸ› Springer 🌐 English βš– 234 KB

Polymorphism of red cell acid phosphatase (ACP-1; E.C. 3.1.3.2.) has been studied using the Cellogel technique of Martin et al. (1975) in 102 patients with psoriasis and 102 healthy controls. In contrast to two previous reports, no anomalies in distribution of phenotypes were found in patients or in