Red Blood Cell Aging

✍ Scribed by Jinhi Ahn, Rose M. Johnstone (auth.), Mauro Magnani, Antonio De Flora (eds.)

• Publisher: Springer US
• Year: 1991
• Tongue: English
• Leaves: 364
• Series: Advances in Experimental Medicine and Biology 307
• Edition: 1
• Category: Library

✦ Synopsis

The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.

✦ Table of Contents

Front Matter....Pages i-x
Front Matter....Pages 1-1
Synthesis of the Transferrin Receptor in Peripheral Sheep Reticulocytes: Evidence for Incomplete Oligosaccharide Processing....Pages 3-13
The Loss of Enzyme Activity from Erythroid Cells During Maturation....Pages 15-27
Role and Mechanism of Hexokinase Decay During Reticulocyte Maturation and Cell Aging....Pages 29-35
Behaviour of Glucose-6-Phosphate Dehydrogenase during Erythroid Maturation....Pages 37-43
Front Matter....Pages 45-45
KCl Cotransport in HbAA and HbSS Red Cells: Activation by Intracellular Acidity and Disappearance During Maturation....Pages 47-57
Conformational Changes and Oxidation of Membrane Proteins in Senescent Human Erythrocytes....Pages 59-73
Selective Binding of Met-Hemoglobin to Erythrocytic Membrane: A Possible Involvement in Red Blood Cell Aging....Pages 75-84
Diabetes Mellitus and Red Blood Cell Aging: A Structural and Functional Study....Pages 85-89
Front Matter....Pages 91-91
Characterization of Senescent Red Cells from the Rabbit....Pages 93-103
The Mechanism of Enzyme Decline in the Red Blood Cell During the “In Vivo” Aging Process....Pages 105-113
The Relationship Between the Blood Oxygen Transport and the Human Red Cell Aging Process....Pages 115-123
Red Cell Metabolism, Normal and Abnormal Implications for Red Cell Aging....Pages 125-137
Significance and Relevance of NAD Synthesis in Human Erythrocyte Life Span....Pages 139-146
Front Matter....Pages 147-147
Hypotheses on the Physiological Role of Enzymatic Protein Methyl Esterification Using Human Erythrocytes as a Model System....Pages 149-160
Heterogeneity of Guanine Nucleotide Binding Proteins in Human Red Blood Cell Membranes....Pages 161-171
Role of Hemoglobin Denaturation and Band 3 Clustering in Initiating Red Cell Removal....Pages 173-183
A Potential, Intracellular Trigger for Removal of Senescent Erythrocyte: Hemoglobin with Methionine Beta (55) D6 Oxidized to the Sulfoxide Derivative....Pages 185-190
Ubiquitin-Mediated Processes in Erythroid Cell Maturation....Pages 191-205
Acylphosphatase and Calcium Transport Across Erythrocyte Membrane....Pages 207-215
Free Radicals Promote “In Vitro” a Different Intracellular Decay of Rabbit Reticulocyte and Erythrocyte Glycolytic Enzymes....Pages 217-223
Front Matter....Pages 225-225
Clinical Utility of Fractionating Erythrocytes into “Percoll” Density Gradients....Pages 227-238
The Role of Red Cell Aging in the Diagnosis of Glycolytic Enzyme Defects....Pages 239-249
Molecular Characterization of Plasma Membrane Calcium Pump Isoforms....Pages 251-261
Human Erythrocyte D-Aspartyl/L-Isoaspartyl Methyltransferases: Enzymes that Recognize Age-Damaged Proteins....Pages 263-276
The Isoenzymes of Mammalian Hexokinase: Tissue Specificity and In Vivo Decline....Pages 277-284
Phagocytosis of Phenylhydrazine Oxidized and G-6-PD Deficient Red Blood Cells: The Role of Sugars and Cell-Bound Immunoglobulins....Pages 285-300
Front Matter....Pages 301-301
Molecular Mapping of the Active Site of an Aging Antigen....Pages 303-316
Recognition Signals for Phagocytic Removal of Favic Malaria-Infected and Sickled Erythrocytes....Pages 317-327
Inhibition by Carbohydrates and Monoclonal Anticomplement Receptor Type 1, on Interactions between Senescent Human Red Blood Cells and Monocytic Macrophagic Cells....Pages 329-337
In Vitro Sequestration of Erythrocytes from Hosts of Various Ages....Pages 339-350
A New Monoclonal Antibody to an Age Sensitive Band 3 Transmembrane Segment....Pages 351-356
Characterization of Antibody that Binds In Vivo to Normal Human Red Blood Cells....Pages 357-365
Opsonic Potential of C3b-Anti-Band 3 Complexes when Generated on Senescent and Oxidatively Stressed Red Cells or in Fluid Phase....Pages 367-376
Back Matter....Pages 377-383

✦ Subjects

Hematology; Biochemistry, general; Animal Anatomy / Morphology / Histology; Plant Sciences