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Recurrent X chromosome-linked deletions: discovery of new genetic factors in male infertility

✍ Scribed by Lo Giacco, D.; Chianese, C.; Ars, E.; Ruiz-Castane, E.; Forti, G.; Krausz, C.


Book ID
121659863
Publisher
BMJ Publishing Group
Year
2014
Tongue
English
Weight
465 KB
Volume
51
Category
Article
ISSN
0022-2593

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Recurrent int22h-related inversions in the coagulation factor VIII gene (F8) are the most common cause of severe hemophilia A. Such inversions have repeatedly been hypothesized to be associated with concomitant deletions that are responsible for an increased risk of immune responses against therapeu