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Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures

โœ Scribed by J. M. Schartner; A. M. Singh; P. E. Dahlberg; L. Nettenstrom; C. M. Seroogy


Book ID
108700949
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
387 KB
Volume
155
Category
Article
ISSN
0009-9104

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## Abstract Naturally occurring CD4^+^ regulatory Tโ€„cells can be identified on the basis of expression of CD25 and suppression of Tโ€„cell responses __in vitro__ after TCR triggering. Here, we demonstrate that a CD134^+^ subset of CD4^+^CD25^+^ Tโ€„cells in naive rats suppresses antigenโ€specific Tโ€„cell