## Abstract A 56‐year‐old woman with an acute promyelocytic leukemia (APL) developed a severe __all‐trans__‐retinoic (ATRA) syndrome on day 17 of treatment. Shortly after, she presented a picture of pancytopenia, hepatosplenomegaly, increased triglycerides, ferritin, and liver enzymes. A bone marro
Recurrent “Retinoic acid syndrome” during induction of remission in acute promyelocytic leukemia
✍ Scribed by Avichai Shimoni; Yaakov Maor-Kendler; Miron Prokocimer
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 195 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0361-8609
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A patient with acute promyelocytic leukemia manifested peripheral blastosis with 50% peripheral blasts and an absolute blast count of 10,0o0/pl 2 weeks after the start of induction chemotherapy. The subsequent disappearance of the peripheral and marrow blasts without further chemotherapy was noticed
Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,