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Recurrent chromosome changes in two adult fibrosarcomas

✍ Scribed by Janusz Limon; Anna Szadowska; Mariola Iliszko; Małgorzata Babińska; Krzysztof Mrózek; Janusz Jaśkiewicz; Andrzej Kopacz; Andrzej Roszkiewicz; Maria Dębiec-Rychter

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
356 KB
Volume
21
Category
Article
ISSN
1045-2257

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✦ Synopsis

Cytogenetic analysis of two adult fibrosarcomas revealed clonal chromosomal rearrangements including unbalanced translocations between chromosomes 2 and 19, with the same segment, 2q21-qter, translocated onto 19p13 in one tumor and 19q13 in another; and partial monosomy of 10q due to add(10)(q22) and del(10)(q22q25) seen in one tumor each. This is the first description of nonrandom chromosomal changes in adult fibrosarcoma.

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