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Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization

✍ Scribed by Xin-Yuan Guan; Song-Bin Fu; Jian-Chuan Xia; Yan Fang; Jonathan S.T Sham; Bao-Dong Du; Hang Zhou; Song Lu; Bai-Qiu Wang; Yi-Zhong Lin; Qiwan Liang; Xiao-Ming Li; Bo Du; Xiao-Ming Ning; Jin-Rong Du; Pu Li; Jeffrey M Trent

Book ID
114134948
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
475 KB
Volume
123
Category
Article
ISSN
0165-4608

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Comparative genomic hybridization (CGH) was used to evaluate and map genomic aberrations in 50 hepatocellular carcinomas (HCCs) from patients chronically infected with hepatitis B virus (HBV). CGH clearly detected nonrandom genomic imbalances. Losses were most prevalent on chromosome regions 4q (70%