Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation
✍ Scribed by Nourani, Amine; Utley, Rhea T; Allard, Stéphane; Côté, Jacques
- Book ID
- 110027644
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 297 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0261-4189
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## Abstract Many mammalian SWI/SNF complexes use Brahma‐related gene 1 (Brg1) as a catalytic subunit to remodel nucleosomes for transcription regulation. In several mesenchymal cells and tissues, expression of a defective Brg1 protein negates the normal activity of the SWI/SNF complex and delays or
In Xenopus and Drosophila embryos, activation of the zygotic genome occurs after a series of rapid nuclear divisions in which DNA replication occupies most of the cell cycle. In these organisms, it has been proposed that zygotic transcription does not begin until a threshold nucleocytoplasmic ratio