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Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergence of HIV from latency

✍ Scribed by Kim, Young Kyeung; Bourgeois, Cyril F; Pearson, Richard; Tyagi, Mudit; West, Michelle J; Wong, Julian; Wu, Shwu-Yuan; Chiang, Cheng-Ming; Karn, Jonathan


Book ID
110031632
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
251 KB
Volume
25
Category
Article
ISSN
0261-4189

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The stability and kinetics of unfolding and refolding of the P167T mutant of the TEM-1 p-lactamase have been investigated as a function of guanidine hydrochloride concentration. The activity of the mutant enzyme was not significantly modified, which strongly suggests that the Glu166Thr167 peptide bo