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Recruitment of heterochromatin protein 1 to DNA repair sites

✍ Scribed by Miroslaw Zarebski; Elzbieta Wiernasz; Jurek W. Dobrucki

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
428 KB
Volume
75A
Category
Article
ISSN
0196-4763

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✦ Synopsis

Abstract

Heterochromatin protein 1 (HP1) was originally identified as a constitutive component of heterochromatin. However it is recognized now that it plays an important role in a number of dynamic processes in the cell nucleus, including transcriptional repression and regulation of euchromatic genes. Recent reports demonstrate that HP1 may be involved in the DNA damage response. Two seemingly contradictory phenomena have been observedβ€”HP1 detachment from chromatin and HP1 recruitment to damaged DNA foci. Based on quantitative FRAP and FLIP studies carefully designed to minimize phototoxicity, we demonstrate that HP1 is recruited to the damaged regions in hetero‐ as well as euchromatin within a few minutes after damage. Β© 2009 International Society for Advancement of Cytometry

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