Distinct regions of cyclinT1 are require
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Alessandro Fraldi; Paolo Licciardo; Barbara Majello; Antonio Giordano; Luigi Lan
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Article
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2001
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John Wiley and Sons
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English
โ 164 KB
Tat-mediated activation of the HIV-1 promoter activity requires Tat-dependent recruitment of the cyclinT1/CDK9 complex (P-TEFb) to the transacting element (TAR) RNA. Tat interaction with the cyclinT1, the regulatory partner of CDK9, results in a speciยฎc recruitment of the heterodimer CycT1/CDK9 comp