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Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat

โœ Scribed by Bieniasz, Paul D.; Grdina, Therese A.; Bogerd, Hal P.; Cullen, Bryan R.


Book ID
119770303
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
511 KB
Volume
17
Category
Article
ISSN
0261-4189

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Distinct regions of cyclinT1 are require
โœ Alessandro Fraldi; Paolo Licciardo; Barbara Majello; Antonio Giordano; Luigi Lan ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 164 KB

Tat-mediated activation of the HIV-1 promoter activity requires Tat-dependent recruitment of the cyclinT1/CDK9 complex (P-TEFb) to the transacting element (TAR) RNA. Tat interaction with the cyclinT1, the regulatory partner of CDK9, results in a speciยฎc recruitment of the heterodimer CycT1/CDK9 comp