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Recovery of immunodeficient mice from a vaccinia virus/IL-2 recombinant infection

✍ Scribed by Ramshaw, Ian A.; Andrew, Marion E.; Phillips, Susan M.; Boyle, David B.; Coupar, Barbara E. H.

Book ID
109750765
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
191 KB
Volume
329
Category
Article
ISSN
0028-0836

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## Abstract Recombinant vaccinia viruses (VV)‐encoding murine interferon‐γ (IFN‐γ) were constructed and the effect of virus‐encoded IFN‐γ on the immune response towards VV __in vivo__ investigated. In athymic nude mice and sublethally irradiated euthymic mice, IFN‐γ expression by VV enabled the mic