Reconstruction of rapidly acquired Germanium-68 transmission scans for cardiac PET attenuation correction
✍ Scribed by Bai-Ling Hsu; James A. Case; Kevin W. Moser; Timothy M. Bateman; S. James Cullom
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 844 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1071-3581
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✦ Synopsis
Background:
Transmission (tx) scan time by use of radionuclide sources for cardiac positron emission tomography prolong imaging and increase the likelihood of patient motion artifacts. a reconstruction algorithm combining ordered-subsets expectation maximization with a bayesian prior was developed and applied to rapid germanium-68 (ge-68) tx scans.
Methods and results:
A cardiac phantom with fluorine-18 (fl-18) was used to determine a minimal count threshold for ge-68 tx scanning. images were acquired over a count range from 2.5 x 10(6) to 8 x 10(7) and for a high-count scan of 1.6 x 10(9) counts to study reconstruction parameters and to determine the minimum tx count threshold. the method was compared against clinical 4-minute tx scans in ten rubidium-82 (rb-82) rest/stress myocardial perfusion studies (body mass index, 30 +/- 4 kg/m(2)). the minimal count threshold was 20 x 10(6), and the mean scan time for the rb-82 studies was 70.5 +/- 3.4 seconds. more than 90% of the segmental scores computed from images acquired via rapid tx scans differed by less than 5% from those obtained with 4-minute tx scans. the mean differences in perfusion scores between the rapid and 4-minute tx scans were 0.46% (95% confidence interval, -1.84% to 0.93%) at rest and 0.39% (95% confidence interval, -1.84% to 1.07%) at stress, demonstrating equivalency of the rapid and 4-minute scans.
Conclusions:
Ordered-subsets expectation maximization with a bayesian prior accurately and efficiently reconstructs rapidly acquired ge-68 tx scans for rb-82 myocardial perfusion positron emission tomography studies.