Recombination in the eukaryotic nucleus

✍ Scribed by P. J. Hastings

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 560 KB
• Volume: 9
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.950090206

✦ Synopsis

Sum ma ry

Mitotic recombination is a repair process which is known to repair double strand breaks and to 3 1 1 double-strand gaps by copying a homologous sequence. Meiotic recombination is a process of heteroduplex formation which sometimes generates crossovers. Evidence is presented that the later stages of meiotic recombination have some characteristics of mitotic repair recombination, leading to the conclusion that mismatch repair may be a recombinogenic repair process. The evidence suggests that the recombinational repair process generates heteroduplex bubbles which can move, Some bubbles become crossovers. Others cease to exist, perhaps because topoisomerase activity breaks them down,