Recombinant vaccinia viruses expressing interleukin-5 stimulate an earlier appearance of antibody-secreting cells in the lung
✍ Scribed by Vijaya Janardhana; Marion Andrew; Sandra Thomas; Barbara Coupar
- Book ID
- 102162538
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 382 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
✦ Synopsis
is a cytokine that participates in the regulation of antibody secretion, in particular promoting the secretion of IgA at mucosal sites. In this report, recombinant vaccinia viruses expressing IL-5 have been inoculated into mice and the appearance of antibody-secreting cells in the spleen and lungs investigated. Although vaccinia virus-expressed IL-5 did not increase the level of IgA in serum, antibody-secreting cells, measured in an enzyme-linked immunosorbent spot assay, appeared earlier in lungs when the immunizing virus expressed IL-5. These early B cells secreted either IgM or IgGI.
* This investigation received financial help from the World Health
Organization as part of its program on basic vaccinology. Current address: TGAL.