Recombinant tumor necrosis factor: its effect and its synergism with interferon-γ on a variety of normal and transformed human cell lines
✍ Scribed by Fransen, Lucie; van der Heyden, Jose; Ruysschaert, Roos; Fiers, Walter
- Book ID
- 122446955
- Publisher
- Elsevier Science
- Year
- 1986
- Weight
- 840 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0277-5379
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## Abstract Interferon‐γ (IFN‐γ) is a product of activated T‐lymphocytes, and tumor necrosis factor‐α (TNF‐α) is a product of both lymphocytes and macrophages. These cell types are often present at sites of tissue damage secondary to chronic infection or autoimmune disease. The purpose of this stud
Human recombinant tumor necrosis factor-alpha (rTNF-alpha, 10(-12)-10(-8) M) inhibited the proliferation of androgen-dependent LNCaP cells by 32-56%. In contrast, proliferation of androgen-independent PC-3 and JCA-1 cells was only slightly inhibited, or not inhibited at all, respectively. Human reco