## Abstract The heterogeneity of the molecular pathology of HCC poses a formidable obstacle to the development of nonβcytotoxic therapies. Several proβtumorigenic signaling pathways can be aberrantly activated in HCC, including those triggered by Wnts. Glypicanβ3 (GPC3), a membraneβbound heparan su
Recombinant soluble glypican 3 protein inhibits the growth of hepatocellular carcinoma in vitro
β Scribed by Mingqian Feng; Heungnam Kim; Yen Phung; Mitchell Ho
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- French
- Weight
- 398 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
β¦ Synopsis
other bacterial components is a distinct possibility. These observations were confirmed in a very similar study in Finland, 10 and a recent meta-analysis, 11 where the summary risk of lung cancer was 0.62 (0.52-0.75) for agricultural workers. The relative risk of lung cancer was below 1.0 for most subgroups defined according to sex, study design, outcome, smoking adjustment and geographic area. These high-quality studies add weight to the hypothesis that occupational exposure to endotoxin in agriculture is protective against lung cancer and could thus pave the way to further preventive strategies.
π SIMILAR VOLUMES
Heparan sulfate proteoglycans (HSPGs) act as coreceptors or storage sites for growth factors and cytokines such as fibroblast growth factor and Wnts. Glypican 3 (GPC3) is the most highly expressed HSPG in hepatocellular carcinoma (HCC). Sulfatase 2 (SULF2), an enzyme with 6-O-desulfatase activity on
Hepatocellular carcinoma (HCC) is a common cause of death from solid organ malignancy worldwide. Extracellular signal-regulated/mitogen-activated protein kinase kinase (MEK) signaling is a critical growth regulatory pathway in HCC. Targeting MEK with a novel small molecule inhibitor, PD0325901, may