Recombinant interferon (IFN) alpha and gamma alter the binding of progenitor cells of patients with CML to fibronectin (FN)

Sequential therapy with recombinant inte

Sequential therapy with recombinant interferons gamma and alpha in patients with unfavorable prognosis of chronic myelocytic leukemia: Clinical responsiveness to recombinant ifn-α correlates with the degree of receptor down-regulation

✍ H. H. Bartsch; K. Pfizenmaier; A. Hanusch; P. Scheurich; U. Ücer; G. A. Nagel 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 710 KB

Natural and recombinant interferons (IFNs) have already demonstrated therapeutic efficacy, including cytogenetic re- missions, in patients with chronic myelocytic leukemia (CML). We investigated at the level of ligand-receptor interaction the question whether heterogeneity of receptor number or affi