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Recombinant human interferon (IFN) alpha-2b in chronic myelogenous leukaemia: dose dependency of response and frequency of neutralizing anti-interferon antibodies

✍ Scribed by Mathias Freund; Peter von Wussow; Helmut Diedrich; Roswita Eisert; Hartmut Link; Hansjochen Wilke; F. Buchholz; S. LeBlanc; Christa Fonatsch; Helmut Deicher; Hubert Poliwoda


Book ID
114711902
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
505 KB
Volume
72
Category
Article
ISSN
0007-1048

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The aim of this study was to determine the sensitivity of transgenic immune tolerant mice for the type and level of aggregation of recombinant human interferon alpha2b (rhIFNa2b). RhIFNa2b was aggregated by metal-catalyzed oxidation or by incubation at elevated temperature and various pHs. Native rh