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Recombinant GM-CSF plus autologous tumor cells as a vaccine for patients with mesothelioma

✍ Scribed by Powell, Alex; Creaney, Jenette; Broomfield, Steven; Van Bruggen, Ivonne; Robinson, Bruce


Book ID
119319363
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
319 KB
Volume
52
Category
Article
ISSN
0169-5002

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Tumor cells transfected to express immunostimulatory cytokines, or admixed with similarly modified bystander cells, are able to induce immune responses against unmodified tumor cells in animal models. For treatment of human patients, a vaccine composed of autologous tumor cells and IL-2-secreting al