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Recombinant-expressed virus-like particle pseudotypes as an approach to vaccine development

โœ Scribed by Laura C. McGuigan; J. Virginia Stallard; Michael Roos; Lendon G. Payne


Book ID
119151873
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
508 KB
Volume
11
Category
Article
ISSN
0264-410X

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Hybrid virus-like particles (VLP) were prepared by self-assembly of the modified porcine parvovirus (PPV) VP2 capsid protein carrying a CD8 + or CD4 + T cell epitope. Immunization of mice with a single dose of these hybrid pseudo-particles, without adjuvant, induced strong cytotoxic T lymphocyte and