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Recombinant adenovirus expressing adeno-associated virus cap and rep proteins supports production of high-titer recombinant adeno-associated virus

✍ Scribed by Zhang, H-G; Wang, Y M; Xie, J F; Liang, X; Hsu, H-C; Zhang, X; Douglas, J; Curiel, D T; Mountz, J D

Book ID: 118676779
Publisher: Nature Publishing Group
Year: 2001
Tongue: English
Weight: 653 KB
Volume: 8
Category: Article
ISSN: 0969-7128
DOI: 10.1038/sj.gt.3301454

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## Abstract ## Background Recombinant adeno‐associated virus (rAAV) has many advantages for gene therapeutic applications in comparison with other vector systems. One of the most promising features is the ability of wild‐type (wt) AAV to integrate site‐specifically into human chromosome 19. Howeve