๐”– Bobbio Scriptorium
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Recognition of Dband Kbgene products by influenza-specific cytotoxic T cells

โœ Scribed by Alain R. M. Townsend; Patricia M. Taylor; Andrew L. Mellor; Brigitte A. Askonas

Publisher
Springer-Verlag
Year
1983
Tongue
English
Weight
739 KB
Volume
17
Category
Article
ISSN
0093-7711

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โœฆ Synopsis

A series of 16 H-2b-restricted, A influenza virus-specific cytotoxic T-cell clones are described and characterized. One is K b restricted, the others D b restricted. The factors governing K b or D b restriction patterns seen in the mixed populations from which clones are derived are investigated. The Kb-restricted clone does not recognize K b mutant bml and influenza and all 15 Db-restricted clones do not recognize D b mutant bin14 and A influenza virus; these results are discussed in the light of findings in a variety of other viral systems. Representative K b-and Db-restricted clones were used to assess the functional properties of cloned cosmids containing either K b or D b genes expressed in transformed L-cells (k haplotype). The expression products of both cosmids functioned efficiently as mutually exclusive restriction elements for A influenza virus recognition.

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