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Recognition of cisplatin adducts by cellular proteins

✍ Scribed by Maria Kartalou; John M Essigmann

Book ID: 114070405
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 450 KB
Volume: 478
Category: Article
ISSN: 0027-5107
DOI: 10.1016/s0027-5107(01)00142-7

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## Abstract Human ovarian carcinoma exhibits a spectrum of responses to treatment with cisplatin, ranging from marked sensitivity to relative resistance. Variations in the efficiency with which cells repair cisplatin‐DNA adducts may in part determine cisplatin sensitivity. We have investigated the