Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions
β Scribed by Gerald T. Nepom; Dawei Ou; Terry P. Lybrand; Carol Deweese; Mary Ellen Domeier; Jane H. Buckner; Leslie A. Mitchell; Aubrey J. Tingle
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 527 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0014-2980
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We studied major histocompatibility complex class II-dependent presentation of two T cell epitopes delivered as synthetic peptides by fixed macrophages. Treatment of bone marrow macrophages with inhibitors of proteinases of the metallo-, aspartic and serine proteinase families enhanced presentation
## Abstract Complexes of major histocompatibility complex (MHC) class II molecules containing invariant chain (Ii)βderived peptides, known as class IIβassociated invariant chain peptides (CLIP), are expressed at high levels in presentationβdeficient mutant cells. Expression of these complexes in mu