Recognition of alloantigens and induction of experimental allergic encephalomyelitis by a murine encephalitogenic T cell clone
β Scribed by Koichiro Sakai; Takeshi Tabira; Tatsuhide Kunishita
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 704 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0014-2980
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T cell receptor (TCR) peptide immunizations have been demonstrated to protect against experimental autoimmune diseases. These findings have led to clinical trials employing TCR peptides in multiple sclerosis and rheumatoid arthritis patients. Previously, we identified a strongly immunogenic region o
Studies from our laboratory have shown that classical clinical and histological signs of experimental allergic encephalomyelitis (EAE) may be induced in Lewis rats by synthetic peptides S49 or S55. Peptides S49S and S55S are defined by residues 69-84 and 72-84 of the guinea pig myelin basic protein