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Recognition of a G-C base pair by α-N7-deoxyinosine within the pyrimidine-purine-pyrimidine DNA triple helical motif

✍ Scribed by Judith Marfurt; Jürg Hunziker; Christian Leumann

Book ID: 104364707
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 254 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00561-6

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✦ Synopsis

The ~t-nucleoside 7-(2'-deoxy-ct-D-ribofuranosyl)hypoxanthine, incorporated into an otherwise 13configured oligodeoxynucleotide that is designed to bind to a DNA duplex in the parallel motif, recognizes selectively and efficiently a G-C base pair, presumably via monodentate ct-H7oG-C base-triple formation.

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