Reciprocal zones of excitation and inhibition in the neostriatum

✍ Scribed by George V. Rebec; Stephen D. Curtis

• Book ID: 104600240
• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 329 KB
• Volume: 2
• Category: Article
• ISSN: 0887-4476
• DOI: 10.1002/syn.890020609

✦ Synopsis

Single-unit activity was recorded in the rat neostriatum at different distances from the point of an infusion of either glutamate or serotonin. In each case, firing rate a t the distant site (0.8-1.5 mm) was the mirror image of that at the near site (0.1-0.3 mm). These reciprocal changes were blocked by a subsequent injection of haloperidol, a dopamine antagonist. It appears that a lateral inhibitory network, intrinsic to the neostriatum and possibly modulated by dopamine, plays an important role in the operation of the neostriatum.