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Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

โœ Scribed by Mucida, D.; Park, Y.; Kim, G.; Turovskaya, O.; Scott, I.; Kronenberg, M.; Cheroutre, H.

Book ID
121368247
Publisher
American Association for the Advancement of Science
Year
2007
Tongue
English
Weight
473 KB
Volume
317
Category
Article
ISSN
0036-8075

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## Abstract Autoimmunity is thought to reflect an imbalance between regulatory Tโ€„helper lymphocytes (Treg) and pathogenic, ILโ€17โ€secreting Tโ€„helper (Th17) cells. Induction of both adaptive Treg and Th17 cells requires signalling from TGFโ€ฮฒ. We now show that, in the context of TGFโ€ฮฒ signalling, allโ€