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Reciprocal Regulation of Endothelial Nitric-Oxide Synthase and NADPH Oxidase by Betulinic Acid in Human Endothelial Cells

✍ Scribed by Steinkamp-Fenske, K.; Bollinger, L.; Xu, H.; Yao, Y.; Horke, S.; Forstermann, U.; Li, H.


Book ID
111904007
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2007
Tongue
English
Weight
403 KB
Volume
322
Category
Article
ISSN
0022-3565

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Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), which has at least three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation. Studies by the avidin-biotin immunocomplex method