Recherche d'analogues de nucléosides à activité antivirale

✍ Scribed by Jean M. J. Tronchet; Miguel J. Valero

• Book ID: 102252457
• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: German
• Weight: 309 KB
• Volume: 62
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19790620828

✦ Synopsis

Search for Antiviral Nucleosides Analogues

In contrast to the reported impossibility of obtaining the expected products when 1‐(2,3‐O‐isopropylidene‐1,5‐dialdoribofurannos‐1‐yl)uracile (2) was treated with stabilized ylides, we prepared in good to excellent yields the modified nucleosides 4–9 by reaction of 2 respectively with acetylmethylidene‐, benzoylmethylidene‐, ethoxymethylidene‐, methoxymethylidene‐, succinimidylidene‐ or N‐phenylsuccinimidylidene‐triphenylphosphorane. Compounds 4–10 were tested against the herpes virus type 1 (HF) and influenza virus A~2~/Scotland. The modified nucleoside 9 showed a limited but significative activity against the herpes virus.