Recessive mutations in the causation of human cancer
โ Scribed by Webster K. Cavenee
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 453 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0008-543X
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The p53 tumour suppressor gene is at the crossroads of a network of cellular pathways including cell cycle checkpoints, DNA repair, chromosomal segregation, and apoptosis. These pathways have evolved to maintain the stability of the genome during cellular stress from DNA damage, hypoxia, and activat