Receptors for sheep erythrocytes (E) and erythrocyte-antibody-complement complexes (EAC) on the lymphoblasts of childhood acute lymphoblastic leukemia
✍ Scribed by Nakazawa, Shinpei ;Minowada, Jun ;Sinks, Lucius F.
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 566 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
Abstract
Two cell‐surface markers, rosette formation with sheep erythrocytes (E‐rosette) as a T‐cell marker and rosette formation with bovine erythrocyte‐antibody‐complement complex (EAC‐rosette) as a B‐cell marker were determined on peripheral blood lymphocytes and lymphoblasts from normal and 89 children with acute lymphoblastic leukemia (ALL).
In the majority of the patients (12/15 untreated patients and 6/11 patients in relapse), lymphoblasts exhibited neither E‐ nor EAC‐rosette formation. Lymphoblasts from one untreated patient with mediastinal mass displayed E‐(50%) and EAC‐rosette formation (15%). In 3 of 11 patients in relapse, lymphoblasts displayed an increase in EAC‐rosette formation with progressive disease. In the remaining patients with active disease, a small and variable proportion of lymphoblasts expressed E and/or EAC‐rosette formation. In 63 patients in remission, percentages of E‐ and/or EAC‐rosette were similar (p > 0.05) to those of control.
The results indicate a wide heterogeneity with respect to expression of lymphocyte membrane markers in lymphoblasts and in normal lymphocytes in patients with active ALL.