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Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma

✍ Scribed by Christoph Harpf; Jörg Dabernig; Christian Humpel

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
351 KB
Volume
25
Category
Article
ISSN
0148-639X

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✦ Synopsis

Abstract

Immunhistochemistry of 10 traumatic human peripheral nerve neuromas and 5 normal digital nerves revealed a high immunoreactivity for the nerve growth factor (NGF) receptors p75 and trkA and the glial cell line–derived neurotrophic factor (GDNF) receptor GFRα‐1. Semiquantitative image analysis showed a significantly increased trkA immunoreactivity in the neuroma group. The presence of the receptors may provide a way to influence therapy of peripheral nerve neuroma by administration of neurotrophins or other substances with binding sites similar to those of a neurotrophic factor. © 2002 Wiley Periodicals, Inc. Muscle Nerve 25: 000–000, 2002

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