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Receptors coupling to G proteins: Is there a signal behind the sequence?

✍ Scribed by Florence Horn; Eleonora M. van der Wenden; Laerte Oliveira; Adriaan P. IJzerman; Gerrit Vriend

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
378 KB
Volume
41
Category
Article
ISSN
0887-3585

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✦ Synopsis

Upon the binding of their ligands, G protein-coupled receptors couple to the heterotrimeric G proteins to transduce a signal. One receptor family may couple to a single G protein subtype and another family to several ones. Is there a signal in the receptor sequence that can give an indication of the G protein subtype selectivity? We used a sequence analysis method on biogenic amine and adenosine receptors and concluded that a weak signal can be detected in receptor families where specialization for coupling to a given G protein occurred during a recent divergent evolutionary process. Proteins 2000;41:448 -459.

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