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Receptor reserve at striatal dopamine autoreceptors: Implications for selectivity of dopamine agonists

✍ Scribed by E. Meller; E. Helmer-Matyjek; K. Bohmaker; C.H. Adler; A.J. Friedhoff; M. Goldstein

Book ID
115880322
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
313 KB
Volume
123
Category
Article
ISSN
0014-2999

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## Abstract The effects of the enantiomers of 3‐hydroxyphenol‐N‐n‐propylpiperidine (3‐PPP) at dopamine (DA) synthesis modulating autoreceptors, measured as DOPA accumulation after decarboxylase inhibition, were assessed in vivo and in rat striatal slices. In vivo, (+)‐3‐PPP inhibited DOPA accumulat