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Receptor occupancy theory-based analysis of interindividual differences in antiemetic effects of 5-HT3receptor antagonists

✍ Scribed by Hideaki Ayuhara; Risa Takayanagi; Kiyoshi Okuyama; Koichi Yoshimoto; Takeshi Ozeki; Haruko Yokoyama; Yasuhiko Yamada


Book ID
106285226
Publisher
Springer
Year
2009
Tongue
English
Weight
295 KB
Volume
14
Category
Article
ISSN
1341-9625

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The effects of serotonin receptor antagonists with differential selectivity for the various classes of 5HT receptors (5HT1, 5HT2 and 5HT3) were tested for their effects on the response to aversive brain stimulation. Electrical stimulation was administered to the dorsal part of the periaqueductal gra