Receptor-mediated uptake of hypertriglyceridaemic VLDL remnants by mouse macrophages in vitro
✍ Scribed by Naruszewicz, M. ;Szostak, W. B.
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 311 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0027-769X
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✦ Synopsis
Following incubation of the VLDL isolated from hypertriglyceridaemic patients with normal human postheparin plasma VLDL remnants were Obtained. '"I-VLDL remnants were taken up and catabolized by mouse macrophages in vitro. This was a receptor-dependent process. Unlabelled VLDL remnants added to the incubation medium inhibited the degradation of '"1-VLDL remnants in the cells. This could not be produced by the presence of VLDL or acetyl-LDL in the medium. It shows that mouse macrophages bind VLDL remnants by means of an other receptor than that for acetyl-LDL. The cell cholesterol content increased after incubation of the cells with VLDL remnants or acetyl-LDL, but not with native VLDL or LDL.