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Receptor-Mediated Interactions between Colloidal Gold Nanoparticles and Human Umbilical Vein Endothelial Cells

✍ Scribed by Dorota Bartczak; Tilman Sanchez-Elsner; Fethi Louafi; Timothy M. Millar; Antonios G. Kanaras

Book ID
104593634
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
534 KB
Volume
7
Category
Article
ISSN
1613-6810

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✦ Synopsis

Abstract

A new strategy to manipulate cell operations is demonstrated, based on membrane‐receptor‐specific interactions between colloidal peptide‐capped gold nanoparticles and human umbilical vein endothelial cells. It is shown that colloidal gold nanoparticles of similar charge and size but capped with different peptide sequences can deliberately trigger specific cell functions related to the important biological process of blood vessel growth known as angiogenesis. Specific binding of the peptide‐capped particles to two endothelial‐expressed receptors (VEGFR‐1, NRP‐1), which control angiogenesis, is achieved. The cellular fate of the functional nanoparticles is imaged and the influence of the different peptide‐coated nanoparticles on the gene expression profile of hypoxia‐related and angiogenic genes is monitored. The findings open up new avenues towards the deliberate biological control of cellular functions using strategically designed nanoparticles.

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